Jurnalul de Chirurgie
 Jurnalul de chirurgie
Aparitie trimestriala in a doua luna a trimestrului
Published quarterly in the second month of the quarter
ISSN: 1584 - 9341 Vol.10 Nr.3 - Iulie-Septembrie 2014 | miercuri, 20 martie 2019
ISSN: 1584 - 9341 Vol.10 No.3 - July-September 2014
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UNREMITTING EARLY STAGE OF HODGKIN DISEASE:
REPORT OF 7 CASES AND BONE MARROW TISSUE IMMUNOHISTOCHEMICAL MARKER STUDY

D. Tamiolakis (1), S. Nikolaidou (1), A. Kotini (2), T. Jivannakis (3), A. Efthimiadou (4),
P. Boglou (5), S. Bolioti (1), J. Venizelos (5)

1. Department of Cytopathology, Regional Hospital of Chania
2. Department of Medical Physics, Democritus University of Thrace, Alexandroupolis
3. Department of Pathology, Regional Hospital of Drama
4. Department of Physiology, Democritus University of Thrace, Alexandroupolis
5. Department of Pathology, Ippokrateion Hospital of Salonica
Jurnalul de chirurgie 2007; 3 (3):260-264
Full text: PDF Format (Engleza/English)

Abstract:

Bone marrow is infrequently implicated in early stage Hodgkin’s disease. We studied the immunohistochemical bone marrow tissue of 7 out of 20 cases with early stage Hodgkin’s disease of the mixed cellularity variant, diagnosed by lymph node biopsy at initial presentation, not responding to radiotherapy alone, in order to examine possible marrow attack. A statistically significant prevalence of CD45, CD45RO, and CD4 positive infiltrates, to the advantage of unremitting hosts, was found. The predominance of CD4 positive cells in the bone marrow space: 1) might be suggestive of involvement in the process; 2) could explain the abnormal cytokine production leading to reduced T-cell immunity and inefficient antitumor response despite the existence of a vast majority of reactive infiltrating immune cells.

KEY WORDS: HODGKIN’S DISEASE, IMMUNOHISTOCHEMISTRY, BONE MARROW

Correspondence to: Tamiolakis Demetrio MD; Regional Hospital of Chania, Crete, Greece, Department of Cytopathology;
Phone: 0030/282.102.2000; Fax: 0030/282.102.2217; e-mail:  



: Creative Commons License
Jurnalul de chirurgie [Journal of Surgery] by Editorial Board, Department of Surgery University of Medicine and Pharmacy Iasi, E. Tarcoveanu, R. Moldovanu is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.
Based on a work at www.jurnaluldechirurgie.ro.