Jurnalul de Chirurgie
 Jurnalul de chirurgie
Aparitie trimestriala in a doua luna a trimestrului
Published quarterly in the second month of the quarter
ISSN: 1584 - 9341 Vol.10 Nr.3 - Iulie-Septembrie 2014 | duminic„, 26 mai 2019
ISSN: 1584 - 9341 Vol.10 No.3 - July-September 2014
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PHYSIOLOGY OF BLOOD COAGULATION (II)
B. Ţuţuianu
Intensive Care Unit, „St. Spiridon” University Hospital Iaşi
Jurnalul de chirurgie 2007; 3 (3):238-248
Full text: PDF Format (Romana/Romanian)

Abstract:

Coagulation cascade was untill recently the only model used to explain the physiological and pathological reactions during clot formation. Dr. Maureane Hoffman and her team suggested a cell-based model for coagulation, which takes place (according to this model) in three phases: initiation, amplification and propagation. This theory does not deny the coagulation cascade. It only says that the leading role in the whole process is held by the cells and that the „intrinsic” and the „extinsic” pathways operate in parallel on different cell surfaces. Using this model, a better understanding of the reactions in vivo during coagulation is achieved, together with answers related to clinical-based questions like „why haemophiliacs bleed?”.


KEY WORDS: COAGULATION, COAGULATION CASCADE, CELL-BASED MODE

Correspondence to: Bogdan Ţuţuianu MD, Intensive Care Unit, „St. Spiridon” Hospital Iaşi, Independenţei Street, No. 1, 700111, Iaşi, Romania; e-mail:  



: Creative Commons License
Jurnalul de chirurgie [Journal of Surgery] by Editorial Board, Department of Surgery University of Medicine and Pharmacy Iasi, E. Tarcoveanu, R. Moldovanu is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.
Based on a work at www.jurnaluldechirurgie.ro.